In Silico Docking Analysis of Anti-malaria and Anti-typhoid Potentials of Phytochemical Constituents of Ethanol Extract of Dryopteris dilatata

Traditional medicinal plants are a possible source of anti-malarial and anti-typhoid medications, there is growing interest in the usage development herbal therapies for these ailments. The study aims to investigate anti-malaria properties of Dryopteris dilataa leaves silico. plant were extracted ethanol analyzed using Fourier transform infrared spectrometer (FTIR) gas chromatography-mass spectrometry (GC–MS). drug likeness ADME predictions done with OSIRIS property explorer ADMETSAR webserver, while molecular docking against dehydrogenase (Malaria target) D-glutamate ligase enzyme (Typhoid Target) was Autodock Vina. FT-IR results indicated presence -OH, CH3, C-H aromatic C=O functional groups GC-MS revealed thirteen (13) potential compounds, nine (9) compounds showed good pharmacokinetic having high human intestinal absorption, less toxic overall score. The  that three compounds, 1,2,3,4,7,8,9,10-Octahydro-12H-[1]benzothieno[2,3-d]pyrido[1,2-a]pyrimidin-12-one (-6.7 Kcal/mol), 4,7,9-Trihydroxy-2-methylnaphtho[2,3-b]furan-5,8-dione (-6.0 1,2,3-Triazol, 2-(E-4,4-dicyano-3-N-methylanilino-1,3-butadien-1-yl)-4-(methoxycarbonyl) (-6.3 gave better score binding affinity than control artesunate (-5.9 Kcal/mol). typhoid also compounds, 4,7,9-trihydroxy-2-methylnaphtho[2 ,3-b]furan-5,8-dione (-8.6 Kcal/mol) 2-(E-4,4-dicyano-3-N-methylanilino-1,3-butadien-1-yl)-4-(methoxycarbonyl)- (−8.3 had reference Ciprofloxacin (-8.1Kcal/mol). research justifies local claims on use strengthens the relevance as promising lead candidates treatment Malaria and typhoid.&nbsp